Trial Designs and Outcomes in Dementia Therapeutic Research

Contents:1. Introduction: Expectations of treatment with cholinesterase inhibition strategy 2. The history of therapeutic trials in dementia 3. Treatment hypoth... » 

Contents:1. Introduction: Expectations of treatment with cholinesterase inhibition strategy 2. The history of therapeutic trials in dementia 3. Treatment hypotheses 4. Clinical trial designs and end-point selection 5. The use of qualitative research in anti-dementia drug trials 6. Inclusion and exclusion criteria 7. Global assessment measures for anti-dementia drug trials 8. Cognitive outcomes 9. Functional outcomes 10. Behavioral outcomes in trials of cognitive agents 11. Quality of life outcomes 12. Caregiver burden outcomes 13. Neuroimaging outcomes 14. Guidelines for randomized clinical studies in Parkinson¿s Disease with Dementia and Dementia with Lewy Bodies 15. Lessons from clinical trials in vascular cognitive impairment 16. Lessons from primary prevention trials in dementia 17. Lessons from trials in moderate to severe dementia 18. Lessons from trials of psychotropic agents in Alzheimer¿s disease 19. Lessons from psychosocial interventions aimed at caregivers of people with dementia 20. Pharmacoeconomic outcomes 21. Executive Dysfunction in Dementia 22. Ethical considerations in the conduct of clinical trials for Alzheimer¿s Disease 23. Designs for trials when there is a standard therapy: superiority, equivalence and non-inferiority 24. Conclusions: Lessons from clinical trials in dementia «