After 13 years there are new areas to discuss and more recent trials to beincluded. Good clinical practice evaluation of quality of life measurement ofthe benef... » 

After 13 years there are new areas to discuss and more recent trials to beincluded. Good clinical practice evaluation of quality of life measurement ofthe benefitrisk comparison determination of cost effectiveness and costutility stopping rules for trials metaanalysis and subgroup analysis are allnew sections. The references are expanded from 305 to 512 and include therecent advances in trial design such as the emnemof1 trials and megatrialsand uptodate examples to illustrate the points made in the 20 chapters. «