From aspects of early trials to complex modeling problems Advances in ClinicalTrial Biostatistics summarizes current methodologies used in the design andanalysi... » 

From aspects of early trials to complex modeling problems Advances in ClinicalTrial Biostatistics summarizes current methodologies used in the design andanalysis of clinical trials. Its chapters contributed by internationallyrenowned methodologists experienced in clinical trials address topics thatinclude Bayesian methods for Phase I clinical trials adaptive twostageclinical trials and the design and analysis of cluster randomization trialstrials with multiple endpoints and therapeutic equivalence trials. Otherdiscussions explore Bayesian reporting methods incorporating compliance intreatment evaluation and statistical issues emerging from clinical trials inHIV infection. «